Cas Number


Other Names

Diethylenimide oxide 1,4-Oxazinane Tetrahydro-1,4-oxazine Diethylene imidoxide Diethylene oximide Tetrahydro-p-oxazine

The formula



Morpholine is an organic chemical compound. This heterocycle features both amine and etherfunctional groups. Because of the amine, morpholine is a base; its conjugate acid is called morpholinium. For example, treating morpholine with hydrochloric acid makes the salt morpholinium chloride.

Physical and Chemical Properties
Physical state and appearance Liquid. (Oily liquid.)
Odor Amine like. (Slight.)
Molecular Weight 87.12 g/mole
Color Clear
Boiling Point 128.19°C (262.7°F)
Flash point CLOSED CUP: 35°C (95°F). OPEN CUP: 38°C (100.4°F).
Melting Point -4.9°C (23.2°F)
Specific Gravity 0.9168 (Water = 1)
Vapor Pressure: 7 mm of Hg (@ 20°C)
Vapor Density 3 (Air = 1)
Volatility 100% (v/v).
Odor Threshold 0.1 ppm
Dispersion Properties See solubility in water
Solubility Easily soluble in cold water
Morpholine by GC,wt% 99.9
Water,wt% 0.03

Morpholine is widely used in organic synthesis. For example, it is a building block in the preparation of the antibiotic linezolid and the anticancer agent gefitinib

In research and in industry, the low cost and polarity of morpholine lead to its common use as a solvent for chemical reactions

Morpholine is used as an aid by the dissolution and emulsifing of shellac, which is used as a wax for fruit coating.

Morpholine derivatives used as agricultural fungicides in cereals are known as ergosterol biosynthesis inhibitors